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3837 - Micro and nanomagnets for biomedicine: from fabrication to cellular up...

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7 months 2 weeks ago - 7 months 2 weeks ago #46 by SofiaAbrunhosa
Oral Presentation
Monday, December 7
Speaker: Raquel Zurbano
Full Title: Micro and nanomagnets for biomedicine: from fabrication to cellular uptake
Last edit: 7 months 2 weeks ago by SofiaAbrunhosa.

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7 months 2 weeks ago #122 by SofiaAbrunhosa
Session questions:
  1. How is biocompatibility handled?
  2. Is it possible to remove the particles in real treatment?

We kindly ask the speakers to reply to any questions left unanswered during the talk.
The following user(s) said Thank You: RZT

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7 months 2 weeks ago #382 by RZT
Thank you very much for the interest and questions
First, in this case the biocompatibility concept is based on the ability of the disks to induce the cell dead after they activation but not before. We want innocuous structures that reach the target cells without adverse effects. Once there, activate the external magnetic field and therefore the mechanical effect that activates apoptosis.
And, in a real treatment we can use the magnetic properties to remove the disc after the treatment, but perhaps the best solution is bioassimilation. If we use iron instead of permalloy, in addition to increasing the magnetic moment, we used a biocompatible material (we eliminated the Ni from the Permalloy). Then the cells themselves could assimilate the Fe itself once the treatment was finished.

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